Effects of dandelion tea on type II collagen induced arthritis in mice by regulation of ROR-γt/Foxp3 signaling

In this study, type II collagen was used to induce arthritis in mice test the effect and mechanism of dandelion tea. The visual manifestations arthritis, histopathological conditions spleen, serum inflammatory factors gene expression synovium foot ankle joints were detected by methods index (AI), spleen index, enzyme linked immunosorbent assay (ELISA), hematoxylin-eosin (H&E) staining quantitative polymerase chain reaction (qPCR). compound components tea determined high performance liquid chromatography (HPLC). experimental results show that can reduce AI value, paw swelling degree mice, pathological damage increase IL-10 TGF-β levels, up-regulate Foxp3 down regulate ROR-γt joint. At same time, component analysis showed efficacy came from contents gallic acid, protocatechuic chlorogenic caffeic p-coumaric rutin, myricetin, isoquercitrin, isochlorogenic acid luteolin. It be seen is a health drink with good intervention on arthritis.